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The SUSTAIN-6 CVOT [67], performed in 3,297 patients with T2DM and ASCVD/CKD, has shown that compared to placebo, semaglutide was associated with increased retinopathy complications (3.0% versus 1.8%
Expected Benefits for Patients and the Healthcare System The GLP-1 Bridge program has the potential to deliver significant benefits for both individuals and the broader healthcare system
However, some secondary measures of nerve impairment did improve, especially in participants with higher cardiovascular risk and moderate BMI.7 Shorter-term trials have shown that 600mg/day of oral racemic ALA reduced neuropathy symptoms like burning, tingling, and numbness in as little as 35 weeks.4 20 A 2010 meta-analysis concluded that oral ALA can improve symptoms of diabetic neuropathy, but noted variability in effect sizes across trials and better results with intravenous administration.1 Despite promising results from some trials, a recent systematic review evaluating eight randomized controlled trials indicates that findings on ALA's effectiveness in treating diabetic neuropathy symptoms are inconsistent.23 While ALA proved safe and tolerable across these studies, the review concluded that definitive evidence supporting significant benefits is limited
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The standard list of side effects for semaglutide is fairly simple: digestive upset, nausea, and symptoms related to dehydration and an imbalanced diet, like headaches and low energy
GLP-1 users face specific nutritional challenges and finding products tailored to these needs can be challenging, said Tabitha Daley, RD, nutritionist with The Vitamin Shoppe who helped formulate the GLP-1 Support from Whole Health Rx products
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